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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
13.33
Human Site:
T454
Identified Species:
22.56
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
T454
C
I
R
S
L
L
C
T
P
I
K
N
G
K
K
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
T454
C
I
R
S
L
L
C
T
P
I
K
N
G
K
K
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
T454
C
I
R
S
L
L
C
T
P
I
K
N
G
K
K
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
T444
C
I
G
S
L
L
C
T
P
I
K
N
G
K
K
Rat
Rattus norvegicus
O54735
833
94538
E434
Q
L
V
N
K
M
E
E
K
T
G
K
I
K
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
P443
I
R
S
L
L
C
T
P
I
K
N
G
K
K
N
Chicken
Gallus gallus
P52731
862
99990
L425
D
E
Q
I
I
E
T
L
T
Q
F
L
G
W
S
Frog
Xenopus laevis
NP_001088271
859
97399
P435
I
Q
S
L
L
C
S
P
I
K
N
A
K
K
N
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
C439
C
Q
I
K
S
L
L
C
T
P
I
R
N
G
K
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
R464
Q
F
S
D
F
H
I
R
S
V
L
C
V
P
I
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
A712
H
R
S
I
L
C
M
A
I
K
N
S
L
G
Q
Honey Bee
Apis mellifera
XP_394107
1016
115998
N491
A
A
T
G
Q
I
L
N
I
G
D
V
T
T
W
Nematode Worm
Caenorhab. elegans
P91119
710
81117
G360
Q
M
V
N
K
H
D
G
V
F
T
R
Q
D
E
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
N441
A
D
S
G
E
T
T
N
I
A
D
F
T
V
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
100
N.A.
N.A.
93.3
6.6
N.A.
13.3
6.6
13.3
20
0
6.6
0
0
0
P-Site Similarity:
100
100
100
N.A.
N.A.
93.3
26.6
N.A.
13.3
20
13.3
20
6.6
20
6.6
20
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
8
0
0
0
0
0
8
0
8
0
8
0
0
8
% A
% Cys:
36
0
0
0
0
22
29
8
0
0
0
8
0
0
0
% C
% Asp:
8
8
0
8
0
0
8
0
0
0
15
0
0
8
0
% D
% Glu:
0
8
0
0
8
8
8
8
0
0
0
0
0
0
8
% E
% Phe:
0
8
0
0
8
0
0
0
0
8
8
8
0
0
0
% F
% Gly:
0
0
8
15
0
0
0
8
0
8
8
8
36
15
0
% G
% His:
8
0
0
0
0
15
0
0
0
0
0
0
0
0
0
% H
% Ile:
15
29
8
15
8
8
8
0
36
29
8
0
8
0
8
% I
% Lys:
0
0
0
8
15
0
0
0
8
22
29
8
15
50
36
% K
% Leu:
0
8
0
15
50
36
15
8
0
0
8
8
8
0
0
% L
% Met:
0
8
0
0
0
8
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
15
0
0
0
15
0
0
22
29
8
0
15
% N
% Pro:
0
0
0
0
0
0
0
15
29
8
0
0
0
8
0
% P
% Gln:
22
15
8
0
8
0
0
0
0
8
0
0
8
0
15
% Q
% Arg:
0
15
22
0
0
0
0
8
0
0
0
15
0
0
0
% R
% Ser:
0
0
36
29
8
0
8
0
8
0
0
8
0
0
8
% S
% Thr:
0
0
8
0
0
8
22
29
15
8
8
0
15
8
0
% T
% Val:
0
0
15
0
0
0
0
0
8
8
0
8
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _